What are these
Chromosomes? How they help us to decide genetical identity? And also, why women
need to undergo PGS during IVF? Does PGS
help to identify genetical disorder in natural pregnancy as well? We have answers
to all your curiosity. Chromosomes play the vital role in the human body.
Chromosomes are two types one is autosome and another one is allosome. Both are
sex chromosomes. These sex chromosomes incorporate 23 pairs of both
chromosomes. Further, these chromosomes are divided into X and Y. X chromosome
is male and XX is female. Y chromosome is female and XY is male. The main
function of the chromosome is to pass progeny and genetic material from parents
to the child that is related to a particular organ of the parents.
Before starting the process
of IVF, PGD is conducted to diagnose any genetical disorder before implanting
the embryo. Then after fertilization on the 5th day, that is the blastocyst
stage, embryologists perform the biopsy of the embryo to confirm the total
number of chromosomes. Preimplantation Genetic Screening (PGS) is performed on
the embryo to confirm the total number of chromosomes that are 46 are present
in the embryo at the blastocyst stage.
Then by using the innovative technique the total number of 46
chromosomes are confirmed within each cell. There are two types of cells found
after the blastocyst stage. One is euploid that contain a normal number of
chromosomes and another one is aneuploid that has an abnormal number of
chromosomes. PGS is performed to avoid abnormal embryo transfer in the uterus.
PGS is an important test
that should be suggested by the Gynaecologist to all pregnant ladies. But if
the doctor is transferring the embryo in the uterus of the women then it should
be confirmed that the embryo is normal and contain all 46 chromosomes.
(Preimplantation Genetical Screening( or (Aneuploidy Screening) that comprises
the examination of the embryos conceived by IVF or ICSI. This procedure is
utilized to recognize common abnormalities. These abnormalities majorly cause
the failure of embryos to implant and of miscarriages or abortions.
To whom we recommend PGS:
PGS is recommended to
those IVF or ICSI patients if:
• The patient has crossed the age of 35 and is diagnosed
with the higher risk of having a child with any chromosomal problem.
• If the patients are having the history of genetical or
• If the women are having a history of miscarriages or
• If a healthy embryo has transferred to the patient and
still IVF outcome of the patient is not successful.
• if the sperm of the male partner is also diagnosed at high
PGS is improving the
implantation and pregnancy rate during IVF. PGS helps to increase live birth
rate. All the improvements are possible due to PGS and this process allows to
transfer embryo without any genetical defect or disorder.